PharmaTrek, a web-based tool developed by M.Carmen Carrascosa, member of the Chemogenomics group of GRIB (IMIM/ UPF) led by Jordi Mestres, within the framework of the EU funded project Open PHACTS, is officially released. Try it out now: http://www.pharmatrek.org This tool offers a totally new way of questioning pharmacology databases in a more interactive manner. Please, have a look at the demo video. Publication Reference: Carrascosa MC, Massaguer OL, Mestres J. PharmaTrek: A Semantic Web Explorer for Open Innovation in Multitarget Drug Discovery. Mol Inf, 2012; 31 (8):537-541. DOI 10.1002/minf.201200070.
Today at 11:00 in the aula 473.10 of PRBB Nuria Radó i Trilla, member of the Evolutionary Genomics group of GRIB (IMIM-UPF), will defend her thesis: "Low-complexity regions in proteins as a source of evolutionary innovation". All of you are invited to this event.
On April 29th at 11:00 at Sala Ramón y Cajal (ground floor) in the PRBB, Alba Jené, member of the Biomedical Genomics group of GRIB (IMIM-UPF) will defend her thesis: "Integrative study of the regulatory and epigenomic programs involved in cancer development"
The review of the eTOX extension proposal (ENSO) was very positively evaluated by IMI JU and an extension until 2016 has been approved. The accomplishments of the eTOX team were highlighted as recommendable and the reviewers also considered it impressive that the eTOX consortium has generated such a large number of high quality publications. The extension will build upon early successes by expanding the acquisition of additional toxicology data inputs (species, types of trials, etc) and allowing access to more public databases. For this purpose four new partners: Fraunhofer ITEM (Germany), Erasmus Medical Center (Holland), University of Leicester (UK) and Universidad Politécnica de Valencia (Spain), will join the consortium, allowing for greater linking between experimental animal and biochemical studies with human outcomes. eTOX project is funded by the Innovative Medicines Initiative Joint Undertaking (IMI-JU) and coordinated by the GRIB.
The project "Elucidating the Network of Breast Cancer" by Eduardo Eyras, head of the Regulatory Genomics Group of GRIB (IMIM-UPF) has been granted by the Sandra Ibarra Foundation of Solidarity Against Cancer. The project aims to carry out an exhaustive analysis of the splicing alterations in breast cancer that can remodel the network of protein-protein interactions. This work will contribute with signatures for breast cancer that may have not been detected before, will provide new knowledge about the role of splicing in breast cancer, and will serve to establish potential new lines of research to find novel therapeutic venues.
The Open PHACTS project has developed a prototype of an iPhone app that provides rapid access to information on compounds of interest to drug developers. A video demonstration of the app on YouTube shows how simply typing the name of a drug into the app delivers information on its chemical structure, function, pharmacology, and latest news relating to it. The app is not yet available as it is still in the early stages of development. Meanwhile, the project team points out that ‘the aim is to show that the next generation of drug discovery APIs [application programming interfaces] make app development so much easier’.
IMI’s drug toxicity project eTOX features in a special issue of the journal Molecular Informatics dedicated to advances in computational technology, a field where eTOX is making significant progress with its computer-based tools and models to predict drug toxicity. The challenges in the field are set out in a guest editorial by eTOX team member Thomas Steger-Hartmann of Bayer. The issue itself includes two contributions from eTOX. One article of the GRIB members Montserrat Cases, Manuel Pastor and Ferran Sanz presents the eTOX public library, which is described as ‘a useful resource for affording the in silico toxicity prediction of novel drug candidates’. A second article signed by researchers of the partner AstraZeneca, discusses the challenge of screening potential drugs for unintended side effects.
LAST WEEK to apply! (deadline 22nd of March) The course will take place from 22nd to 26th of April 2013 at Barcelona Supercomputing Center and provides insight on the different integrative and translational research approaches in the field of Bioinformatics. The students will meet internationally renowned experts in the field and gain knowledge about the current challenges and opportunities in the emerging field of translational bioinformatics. The course is targeted to graduate students with background on: Bioinformatics, Medical Informatics, Medicine, Biology, Chemistry, Biochemistry, Pharmacy, Mathematics, Physics, Biomedical Engineering or related areas and is organized by the european FP7 project INBIOMEDvision led by the GRIB. Click here for application form and other details
Three Catalan universities (UAB, UPC and UPF) and representatives of ten biological and biomedical research institutes, together with the Barcelona Supercomputing Center (BSC) and BioCat, last week signed an agreement to create Bioinformatics Barcelona (BiB), a platform which aims to promote training, research, and the transfer of technology in bioinformatics and hopefully will turn the Barcelona area into an international point of reference in the field of bioinformatics through cooperation between universities, centres of research, and other public and private entities.
La innovación en abierto es ya una realidad en la investigación biomédica. Hoy más que nunca es necesario contar con las aportaciones de todos los agentes públicos y privados para transformar de forma eficiente el conocimiento científico en innovaciones que mejoren la salud de las personas. Esta sexta Conferencia repasa las actividades de las cuatro plataformas de investigación biomédica en 2012 y debate aspectos clave que marcarán los proyectos para los próximos años.