Descifrando el genoma de los tumores para avanzar hacia la medicina personalizada del cáncer

Núria López -Bigas y su equipo del grupo de Genómica Biomédica del GRIB (IMIM- UPF) han recopilado y estudiado las mutaciones descritas en 4.623 tumores originados en trece órganos diferentes para identificar los genes implicados en el desarrollo de la enfermedad y avanzar hacia la medicina personalizada del cáncer. Los resultados se han publicado en la revista Nature Methods.

Los autores han declarado que "algunos de los genes clave que hemos identificado codifican proteínas que son posibles dianas para nuevos tratamientos contra el cáncer " y "además, esta información podría ayudar a afinar el diagnóstico de cada paciente para utilizar las estrategias terapéuticas existentes más adecuadas, e identificar marcadores para la detección precoz de la enfermedad".

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Abel González-Pérez, Christian Pérez-Llamas, Jordi Deu-Pons, David Tamborero, Michael P Schroeder, Alba Jené-Sanz, Alberto Santos, Nuria López-Bigas (2013), “IntOGen-mutations identifies cancer drivers across tumor types”,  Nature Methods, 10.1038/nmeth.2642, 15 de septembre.

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Thesis defence of Xavier Jalencas "Chemoisosterism and its impact on drug polypharmacology"

On September 17th, Xavier Jalencas, member of the Systems Pharmacology Group of GRIB (IMIM-UPF) will defend his thesis at 12.00 at the PRBB Auditorium. You are all invited to this event.

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The integrity of the human genome depends on a protein complex that controls the behavior of mobile DNA

Researchers of the Regulatory Genomics group of GRIB (IMIM/ UPF) led by E. Eyras have participated in this study published at Nature Structural and Molecular Biology Journal, which describes the mechanism by which most human cells can avoid being "bombarded" by mobile DNA fragments. This repetitive DNA has the ability to make a copies, which get inserted into other locations in the genome.

Article Reference:
Heras SR, Macías S, Plass Mireia, Fernández N, Cano D, Eyras E, García-Pérez JL, Cáceres JF. The Microprocessor controls the activity of mammalian retrotransposons. Nat Struct Mol Biol, 2013

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Thesis defence of Juan Ramón González-Vallinas "Software development and analysis of High Throughput Sequencing data for genomic enhancer prediction"

On September 9th, Juan Ramón González-Vallinas , member of the Computational Genomics Group of GRIB (IMIM-UPF) will defend his thesis at 11:30 at the Charles Darwin Room. You are all invited to this event.

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Translational Knowledge Management

Workshop on Translational Knowledge Management in Pharmaceutical R&D

The workshop, organised by INBIOMEDvision and hosted by the Innovative Medicines Initiative, will take place the 11th and 12th of July in Brussels and aims at offering a forum for awareness, discussion and interaction between key stakeholders for the development and implementation of innovative concepts and tools for innovative and effective translational and integrative knowledge management (KM) in pharmaceutical research. The participants are key representatives of IMI KM projects and from other related projects also funded by the European Commission, as well as other experts from Europe, USA and Japan.

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July 25th, 2013

Thesis defence of Steve Laurie "Mutation, duplication, and selection in mammalian genomes"

On July 25th, Steve Laurie, member of the Evolutionary Genomics Group of GRIB (IMIM-UPF) will defend his thesis at 11:00 at Aula Room of PRBB.

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Chemogenomics group is now Systems Pharmacology group

In its 10th anniversary, the Chemogenomics group of GRIB lead by Jordi Mestres has changed its name to Systems Pharmacology group.  This new name aims to better reflect the evolution of this research group from its original focus on protein families to a systems view of chemical biology and drug discovery. 

You can follow the activities of this group at the new website

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Thesis defence of Eneritz Agirre: "Epigenetics in alternative splicing: links between chromatin structure, transcription and non-coding RNA mediated regulation"

On June, 21st at 11:30 at the Xipre room of the PRBB, Eneritz Agirre, member of the Regulatory Genomics group of GRIB (IMIM-UPF) will defend her thesis. You are all invited to this event.

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Open PHACTS apps get developer community buzzing

Experts from across Europe and beyond gathered in London at the end of April for the public release of the OpenPHACTS application programming interface (API) during the project’s Community Workshop. The API allows researchers to access and query the vast amounts of data compiled by the Open PHACTS project, creating their own, customised apps to do so if needed. The workshop featured demonstrations of two apps based on the API. PharmaTrek  developed by researchers of GRIB provides with an intuitive tool to explore the reams of target-protein interaction data that are publicly availabl e. Meanwhile, the ChemBioNavigator  app allows users to rapidly and easily compare the physicochemical properties of a molecule set.

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UPF held an international course on Translational Bioinformatics

This 1-week course followed the series of multidisciplinary and innovative training activities organised by the project INBIOMEDvision and was held on the 22-26th of April at the Barcelona Supercomputing Centre (Spain) facilities at the lively University zone located uptown of Barcelona. The course was targeted to post graduate students with interest in the different integrative and translational research approaches in the field of Bioinformatics.

A group of 30 students from 10 different countries were selected to take part in the course based on personal motivation and previous study and research background with a special focus on translational and integrative studies.

The course was jointly organised with the Pompeu Fabra University (UPF), the Bioinformatics Barcelona (BIB), Barcelona Supercomputing Center (BSC), the Spanish Technological Platform for Innovative Medicines (PTEMI), and the Spanish Institute of Bioinformatics (INB). The organising and selection commitee was chaired by Dr. Laura I. Furlong (GRIB, IMIM-UPF), and other members were Prof. Ferran Sanz and Dr. Núria López-Bigas (GRIB, IMIM-UPF).

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