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6/10/2011

Certara to Distribute Leading Software for Predicting Off-Target Effects of Small Molecules developed by Chemotargets, the first spin-off company of IMIM

Certara, a leading provider of software and services to improve productivity and decision-making from drug discovery through clinical development, announced that it will be the exclusive provider of Chemotargets software for predicting the off-target pharmacology of small molecules.

Chemotargets emerged in 2006 as a spin-off company of the Chemogenomics Laboratory of GRIB led by Dr. Jordi Mestres. “In the last few years, it has been shown that our perception of drug selectivity has been historically biased by the limited amount of pharmacological data available; having a computational tool that allows for extending the currently known target affinities with additional predicted off-target affinities is a means to having a more realistic picture of how drugs may actually exert their action,” said Dr. Mestres.

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GRIB volley teams awarded in the PRBB finals of the Beach Volleyball Championship

The Sandrover team was awarded as the best of 4*4 championship and the Vollywood team was awarded with the "Fair play prize" and the "most original team name prize". They did not miss the traditional swim in the sea. Congratulations to all the participants!!

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15/7/2011

La bioinformàtica permet tenir un coneixement modular de les malalties genètiques

La recerca s'ha publicat a mitjans de juny en la revista Public Librery of Science ONE.

Un equip d'investigadors del GRIB (UPF-IMIM), conjuntament amb investigadors de la Universitat de Munic (Alemanya), a partir de la xarxa DisGeNET desenvolupada per l'equip que coordina  Laura Furlong, investigadora  del grup d'Informàtica Biomèdica Integrada del GRIB (UPF-IMIM), han realitzat un treball en què, a més d'una exhaustiva descripció dels gens relacionats amb les malalties considerades, ha tingut en compte altres aspectes biològics que concorren en una determinada malaltia o grup de malalties. La recerca s'ha publicat a mitjans de juny en la revista Public Librery of Science ONE.

Treball de referència:Bauer-Mehren A, Bundschus M, Rautschka M, Mayer MA, Sanz F, Furlong LI (2011), " Gene-Disease Network Analysis Reveals Functional Modules in Mendelian, Complex and Environmental Diseases", PLoS ONE, 6(6): e20284

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El GRIB forma part de la delegació catalana que assisteix a BIO Washington 2011

La trobada mundial més important del sector biotecnològic se celebrarà aquest any, del 27 al 30 de juny, a Washington DC

La trobada mundial més important del sector biotecnològic se celebrarà aquest any, del 27 al 30 de juny, a Washington DC, la capital dels Estats Units, i un dels nuclis en ciències de la vida que més ha crescut en aquest país els darrers anys. Les oportunitats que ofereix la localització d’aquesta propera edició de la BIO International Convention són tant de l’àmbit pròpiament biotec i farma com del polític

El GRIB (IMIM-UPF) hi participa en el marc del estand del Biocat, conjuntament amb 17 centres de recerca i institucions catalanes, a través del seu responsable de transferència. La participació global d'entitats catalanes és de 59, entre empreses amb estand propi, institucions i empreses acollides pel Biocat.

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Biomedicina computacional y efectos adversos (Diario Médico, 23/6/2011)

Contra los riesgos, cualquier seguridad es poca. En el caso de los fármacos, una de las últimas armas es la biomedicina computacional. Aquí entra el proyecto europeo EU-ADR, dentro del cual se sitúa un trabajo de sustanciación de señales de farmacovigilancia. Hasta que finalice el presente año, los investigadores se afanarán en lograr métodos mediante los cuales puedan descubrir posibles efectos adversos de los medicamentos.

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7/6/2011

A major step in molecular simulation - key to designing new drugs

The research has been published online in the prestigious magazine Proceedings of the National Academy of Sciences (PNAS)

Researchers of GRIB (IMIM/ UPF) have successfully reproduced and reconstructed the complete process of a small molecule binding with its target protein. This advance enables the drug's affinity and binding level with the protein to be calculated as well as understanding the interactions established by the drug in order to act, thus moving towards safer and more efficient design of new drugs.

This groundbreaking project helps show a process that was hitherto invisible and therefore unknown, and opens up a new avenue in the design of new drugs.

Reference article:"Complete reconstruction of an enzyme-inhibitor binding process by molecular dynamics simulations" I Buch, T Giorgino, G De Fabritiis.

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3/6/2011

eTOX in heart toxicity test breakthrough

Scientists of GRIB (IMIM-UPF) in the IMI project eTOX  have developed a computer model to test potential medicines for cardiotoxicity. Currently, many promising drug candidates fail because they turn out to cause serious heart problems in patients. The new eTOX system should help researchers pick up on these problems earlier on in the drug development process. Users simply have to enter the molecular formula of the compound into the tool, and the system generates a simulated ECG (electrocardiograph). Clinicians routinely use ECGs to diagnose heart problems in their patients; in the same way, users can study the simulated ECG generated by the eTOX system to determine whether or not a compound is toxic to the heart. ‘It provides better results than the currently used computational systems,’ commented eTOX project coordinator Ferran Sanz of Fundació IMIM in Spain.

Publication ref.: Obiol-Pardo C, Gomis-Tena J, Sanz F, Saiz J, Pastor M. A Multiscale Simulation System for the Prediction of Drug-Induced Cardiotoxicity. Journal of Chemical Information and Modeling, 2011.

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3/6/2011

Semantic 'lego': an information framework to drive drug discovery (Press Release)

A new consortium of European organisations unite to support next generation drug discovery by providing a single view across data sources, bringing the semantic web to drug discovery.

The Open PHACTS consortium, funded by the Innovative Medicines Initiative, will reduce the barriers to drug discovery by applying semantic technologies to available data resources, creating an Open Pharmacological Space.

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20/5/2011

GRIB organizes a Course on Bioinformatics for Integrative Genomics

We are pleased to announce that registration for the Course on Bioinformatics for Integrative Genomics for June 21th- 22th at UPF facilities is now open.The course is organized by the Biomedical Genomics lab of GRIB (IMIM-UPF).

The objective of the course is to provide theoretical and practical expertise in the field of bioinformatics for integrative genomics. Attendees will learn how to handle and analyze genomic data to answer specific questions using tools developed in the Biomedical Genomics lab: IntOGenGitools and Condel.

Registration is free, but limited places available. We strongly recommend you to register asap. To register: send a CV and a motivation letter to Melquíades Calzado(mcalzado@imim.es).

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27/4/2011

Jornada sobre patents en l'àmbit de la Biomedicina

Auditori del Parc de Recerca Biomèdica de Barcelona de 10:00 a 14:00h

En el marc de la Plataforma Tecnológica Española de Medicamentos Innovadores, copresidida per Ferran Sanz, director del Programa de Recerca en Informàtica Biomèdica de l'IMIM (Institut de Recerca Hospital del Mar), s'organitza el proper 24 de maig a l'Auditori del Parc de Recerca Biomèdica de Barcelona (PRBB), una Jornada sobre patents en l'àmbit de la biomedicina. Aquesta jornada està dirigida pel professor Pascual Segura, agent de la propietat industrial de la Universitat de Barcelona i director del seu centre de patents. L'objectiu de la Jornada és explicar la importància dels drets de propietat industrial, què es pot patentar i sota quines condicions, entre molts altres temes.

La inscripció que és gratuïta podeu realitzar-la clicant aquí.

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