"'To be or not to be, that is the question': The role of the ZRF1 gene in embryonic and cancer development"

The work, published in the journal Nature, was led by the ICREA professor Luciano Di Croce (CRG), with the participation of Núria López-Bigas and Gunes Gundem, head and predoctoral research respectively of the Biomedical Genomics laboratory of GRIB (IMIM/ UPF) and shows that the gene ZRF1 carries out a crucial role in the activation of genes related to the cellular destination of stem cells. 

The project was financed by the Minister of Science and Innovation through the Plan Nacional de Investigación, Desarrollo e Innovación and by the Association for International Cancer Research.

Publication Reference: Richly H, Rocha-Viegas L, Domingues Ribeiro J, Semajo S, Gundem G, López-Bigas N, Nakagawa T, Rospert S, Takashi I and Di Croce L. (2010). “Transcriptional activation of polycomb-repressed genes by ZRF1” Nature. DOI: 10.1038/nature09574  

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Ignasi Buch granted at the MGMS Young Modellers' Forum 2010

Ignasi Buch, member of the Computational Biophysics laboratory of GRIB (IMIM-UPF) was granted with the"best presentation award" in the MGMS Young Modellers' Forum 2010 celebrated in London last 10th of December.
The presentation title was "Energetics, kinetics and binding pathway reconstruction for enzyme-inhibitor complex from high-throughput MD simulations". See abstract (talk7).

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Les proteïnes, unes molècules complexes essencials per a la vida

El Laboratori de Biofísica Computacional del GRIB (IMIM-UPF) estudia les proteïnes a través de simulacions per ordinador per saber com funcionen i com interactuen amb els fàrmacs. Ver video.

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Thesis of Anna Bauer: Integrative approaches to investigate the molecular basis of diseases and adverse drug reactions: from multivariate statistical analysis to systems biology.

Anna Bauer, member of the Integrative Bioinformatics laboratory of GRIB (IMIM/ UPF) will defence her thesis the 8th of november at 11:30 at PRBB Auditorium.

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La simulación multiescala, útil para predecir cardiotoxicidad

La toxicidad que causan algunos fármacos sobre órganos vitales como el corazón, el hígado o el cerebro, representa uno de los grandes obstáculos en los ensayos clínicos. Los nuevos modelos de predicción por simulación matemática abren nuevos horizontes en este campo.

Ver Artículo en Diario Médico del 13 de Octubre 2010

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La medicina del futur

Debat televisiu on va participar Jordi Villà, cap del laboratori de Bioquímica i Biofísica Computacional del GRIB (IMIM/ UPF) al programa ANGLES de la Televisió L'H

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Molecular modeling makes impact !

The members of the group Computer-Assisted Drug Design (CADD) in the GRIB (IMIM/ UPF), Laura López, Cristian Obiol-Pardo and Jana Selent have competed very successfully in the organized international competition "GPCR Dock 2010" promoted by the group of Raymond C. Stevens (Scripps Research Institute of California).

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L’Ésser Humà Virtual: simulant el funcionament del cos humà

Com podem usar les matemàtiques per entendre els processos fisiològics?

El divendres 8 d’octubre va acabar la reunió del segon grup d’estudi de la Virtual Physiology Human Network of Excellence (VPH NoE), una xarxa d’excel·lència europea que, durant 5 anys, està coordinant una sèrie d'activitats relacionades amb el desenvolupament de l'Ésser Humà Virtual, amb l’objectiu de generar simulacions de models multiescala que reprodueixen el funcionament del cos de la mol·lècula a l’òrgan.

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Nils Drechsel won the best poster award at the VPH conference 2010 in Brussels

Nils Drechsel, member of the Computational Biochemistry and Biophysics Laboratory, won one of the two poster awards for the best poster at the VPH conference 2010 in Brussels which took place early October. The poster with the title "Implementation of a Multiscale Model for Molecular Dynamics Simulations of Protein Folding and Aggregation" compromises the recent advancements in multiscale molecular dynamics, as well as developments regarding the molecular simulator ADUN.

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Thesis of Adrian López: Computational Approaches to the Modelling of Topological and Dynamical Aspects of Biochemical Networks. PRBB, October the 19th at 11:00

Adrián López, member of Computational Biochemistry and Biophysics laboratory of GRIB (UPF/ IMIM) will defence his thesis the 19th of October 2010 at 11:00 in the Parc Recerca Biomedica de Barcelona (PRBB) at XIPRE Seminar at the 1st floor of the building.

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