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21/03/2018

XI Conferencia anual de las plataformas de investigación biomédica

Los días 5 y 6 de marzo se celebró en Barcelona la XI Conferencia Anual de las Plataformas Tecnológicas de Investigación Biomédica: Medicamentos Innovadores, Nanomedicina,  Tecnología Sanitaria y Mercados Biotecnológicos, en la que se presentaron diferentes avances en el ámbito de la innovación biomédica disruptiva en el abordaje de diferentes patologías.

La conferencia contó con la participación de más de 50 ponentes y 250 asistentes del sector público y privado. Ferran Sanz, Director del GRIB, junto con Javier Urzay, ambos co-Presidentes de la Plataforma Tecnológica Española de Medicamentos Innovadores, presentaron las actividades realizadas por esta plataforma en 2017

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ECTB 2018 speakers

04/12/2017

Join the 3rd European Conference on Translational Bioinformatics: Biomedical Big Data Supporting Precision Medicine

The conference will be held at Barcelona Biomedical Research Park (PRBB) on April 16-17th 2018. This meeting follows on from the success of the European Conference on Translational Bioinformatics (ECTB) series hold in 2016 at the University of Copenhagen, Denmark; and in 2017 at the European Bioinformatics Institute, UK. As in past editions, the 2018 meeting will bring together scientists, developers, and entrepreneurs who are interested in translating genomics and bioinformatics research into healthcare tools and services. The meeting will be relevant for researchers, computational biologists and entrepreneurs from start-ups and established companies interested in epidemiology, cancer genomics and precision medicine.

The Conference is organized by the GRIB (IMIM-UPF) jointly with BSC and supported by the EU project MedBioinformatics and the Spanish Institute of Bioinformatics (INB).

Click here for Registration

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16/03/2018

Thesis lecture of Mari Carmen Carrascosa: "Next generation of informatics tools for big data analytics in drug discovery"

Next Tuesday 20th of March at 11h, Mari Carmen Carrascosa , member of the Systems Pharmacology group of GRIB will defense her thesis "Next generation of informatics tools for big data analytics in drug discovery" at the Classroom number 61.127, placed at the first floor of the Doctor Aiguader building (Dr. Aiguader 80). You are all invited to this event.

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8 de març: Concentració pel dia de la dona treballadora

El dijous 8 de març hi ha convocada una concentració a les 11'30h a la plaça interior del PRBB amb motiu del dia de la dona treballadora. El Dia Internacional de les Dones o Dia de la Dona Treballadora és una commemoració anual reconeguda per l'Organització de les Nacions Unides i que denuncia el sexisme i la desigualtat de drets i oportunitats entre homes i dones.

Aquest mateix dia hi ha dues concentracions reivindicatives més, una convocada per les entitats sindicals a les 12 del migdia davant dels Ajuntaments i una a les 18,30 hores, a Passeig de Gràcia amb Diagonal, convocada per diverses organitzacions i institucions per a la celebració d' una manifestació unitària.

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05/03/2018

El GRIB ha aconseguit un doctorat industrial en la convocatòria del 2017

El GRIB ha obtingut un ajut de Doctorat Industrial  a la convocatòria 2017 d'aquest programa gestionat per l'AGAUR que vol afavorir la transferència de coneixement al sector productiu.

El projecte anomenat "Play Molecule: Developing a web platform for biomedical applications" anirà a càrrec del doctorand Alejandro Varela, que tindrà com a director de tesi Gianni de Fabritiis, professor d'investigació ICREA i cap del grup de recerca en Biofísica Computacional del GRIB (IMIM-UPF).

El projecte, que es realitzarà amb l'empresa Acellera Labs, consistirà en el desenvolupament de noves eines bioinformàtiques estructurals i la seva implementació a playmolecule.org, una plataforma en línia que ofereix solucions bioinformàtiques a problemes comuns en aquest camp.

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5/03/2018

eTRANSAFE 2nd Consortium Meeting in Basel

The 2nd eTRANSAFE Consortium Meeting was held in Basel (Switzerland) on the 6th and 7th of February 2018, where members of the 26 partners of the Consortium met to share research outcomes from the first 6 months of the project life, as well as to discuss on project specific topics such as Data collection, interoperability and integration. In addition to presentations from the 10 Work Packages, parallel sessions were organised to emphasise efforts on Modelling and Data Sources.

eTRANSAFE is expected to build upon the success of eTOX, for this the use of eTOX assets such as eTOXsys and OntoBrowser was addressed during the meeting. The need to develop an adequate sustainability plan from the very beginning of the project, and the importance of promoting and disseminating the information and the knowledge generated were also discussed, as the creation of a task force aimed at addressing the collection of data (both preclinical and clinical) by the EFPIA companies from a common perspective.

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19/02/2018

The 2nd annual conference Bermuda Principles - Impact on Splicing is coming

The 2nd annual conference Bermuda Principles - Impact on Splicing (BPIS) will be held on February 21 - 25th, 2018. Eduardo Eyras, head of the Computational RNA Biology group of GRIB (UPF-IMIM) takes part in the organization of this event.

The inaugural BPIS Conference that took place in February 2017 was a great success, consolidating it as annual event on the scientific calendar. In 2018 this exciting conference will feature a distinguished Keynote Lecture by Professor Adrian Krainer, presentations by six keynote speakers representing a wealth of countries including Italy, Scotland, England and the USA, and a further array of speakers from the USA, Switzerland, South Africa and Australia. The conference topics include: Splicing mechanisms; RNA structure; RNA - protein interactions; Bioinformatics; Splicing and disease; Links to transcription; Therapeutics and translational applications.

For further information about the conference please visit the website htps://www.bermudaprinciples.org/

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09/02/2018

Project eTOX close out meeting held in Brussels

On January 25th, the eTOX Executive Committee members François Pognan (Novartis Pharma), Ferran Sanz (FIMIM), Thomas Steger-Hartmann (BHC) and Carlos Díaz (SYNAPSE) held the close out meeting of the eTOX project at the IMI´s offices in Brussels. IMI´s Executive Director Dr Pierre Meulien also attended the meeting. The main points addressed during the meeting were project's objectives and outcomes, impact, sustainability and lessons learned.

The eTOX project stems from the very first IMI Call (it started in 2010) and was the very first IMI project coordinated by FIMIM. The project successfully ended in December 2016. With a budget of over 18.5 million €, the project was undertaken by a consortium of 30 organisations led by Novartis, among which 13 EFPIA companies, 11 academic partners, and 6 SMEs. The eTOX project aimed to build a toxicology database and novel software tools to better predict in-vivo toxicology of new chemical entities in early stages of the drug development pipeline.

The eTOX project leaves behind as main assets: eTOXsys - a tool to facilitate the safety assessment of new drug candidates; OntoBrowser - a tool to support community-based ontology development; eTOXlab - a platform for the development and maintenance of the models. These tools are an important legacy that will be further used within eTRANSAFE, an IMI-2 project recently started, that is expected to build upon the success of eTOX.

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Closing in on advanced prostate cancer

The incidence of prostate cancer is increasing worldwide. In the US and Europe, it is one of the most common tumours and among the main causes of death by cancer. In most cases, prostate cancer is cured by surgical removal of the tumour and/or by radiotherapy. However, 20% of patients will need treatment to remove tumour cells but this treatment ceases to be effective after two or three years and the cancer develops further. Once this stage of the disease has been reached, there is no cure. A team headed by Xavier Salvatella, ICREA researcher at the Institute for Research in Biomedicine (IRB), including the participation of Gianni de Fabritiis, ICREA researcher and head of the Computational Biophysics group of GRIB,  has discovered a new avenue through which to attack prostrate cancer cells that have developed drug-resistance. Published in the journal Structure, part of the Cell group, the study opens up new therapeutic avenues against a disease that causes 75,000 deaths a year in Europe alone (source: European Science Hub, 2015).

Reference article: De Mol E, Szulc E, Di Sanza C, Martínez-Cristóbal P, Bertoncini CW, Fenwick RB, Frigolé-Vivas M, Masín M, Hunter I, Buzón V, Brun-Heath I, García J, De Fabritiis G, Estébanez-Perpiñá E, McEwan IJ, Nebreda ÁR, Salvatella X. Regulation of androgen receptor activity by transient interactions of its transactivation domain with general transcription regulators.  Structure (2017) https://doi.org/10.1016/j.str.2017.11.007

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04/12/2017

Genes identified that distinguish mammals from other animals

Researchers from GRIB (IMIM-UPF) have analysed the genome of 68 mammals, including our own species

What distinguishes Homo sapiens from other living beings? And the group of mammals? What makes them different? These are the questions that researchers from GRIB and UPF have been trying to answer. To do this, they analysed the already-sequenced genomes of 68 mammals and identified 6,000 families of genes that are only found in these animals. These are genes with no homologues outside mammals, in other words, they are not present in other hairless species. In humans, it is estimated that they represent 2.5% of the genes that code for proteins. The work was led by Dr. José Luis Villanueva-Cañas, a member of the Evolutionary Genomics group of GRIB and currently a researcher at the Evolutionary Biology Institute (UPF-CSIC), and Dr. Mar Albà, ICREA researcher and head of the Evolutionay Genomics group of GRIB. The study also involved Dr. David Andreu's group from the UPF's Department of Experimental and Health Sciences. It has been published in the journal Genome Biology and Evolution.

Reference article: Villanueva-Cañas JL, Ruiz-Orera J, Agea MI, Gallo M, Andreu D; Alba MM. New Genes and Functional Innovation in Mammals. Genome Biology and Evolution, 2017; 9, 1886-1900. DOI: 10.1093/gbe/evx136

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