Tools
The CBBL, awarded in the new edition of the “marató de TV3″ projects
The Computational Biochemistry and Biophysics Laboratory of GRIB has been awarded in the new edition of the “Marató de TV3” basic research projects call. The awarded project deals with the study of the modulation of microglia/macrophage response by targeting novel immune receptors regulating cell activation and phenotype, which will provide neuroprotection after acute CNS damage. As public researchers we take this new challenge with renovated energy, and taking into account the individual contributions of many anonymous people we will put all our efforts to produce a succesful outcome of the project.
Join us at the XI Jornadas de Bioinformática in Barcelona. Registration is now open!
We are only 15 days away from end of Early Registration ( and abstract submission to the "XI Jornadas de Bioinformática", which is to be held at the PRBB in Barcelona between the 23rd and the 25th of January 2012 and organized by the Spanish Institut of Bioinformatics and the Portuguese Bioinformatics Network. IMPORTANT DATES • Early Registration deadline: 30th of November 2011 • Deadline for submission of papers and highlight proposals: 30th of November 2011 • Notification of acceptance: 30th of December 2011 Please, follow these links for details on how-to submit your work (http://jbi2012.org/?page_id=23) as well as the formatting instructions (http://jbi2012.org/?page_id=224). We look forward to meeting all of you in Barcelona!
18/10/2011
Pyicos: A versatile toolkit for the analysis of high-throughput sequencing data
This new tool framework, developed by the Regulatory Genomics Group of GRIB (IMIM-UPF), is used for the analysis of various data types following from experiments of RNA sequencing (RNA-Seq) as well as Chromatin immunoprecipitation (ChIP-Seq) or Cross-linking immunoprecipitation (CLIP-Seq). Pyicos is available at http://sourceforge.net/projects/pyicos/ Publication reference: Althammer S, Gonzalez-Vallinas J, Ballare C, Beato M, Eyras E. Pyicos: A versatile toolkit for the analysis of high-throughput sequencing data. Bioinformatics. 2011 Oct 12. [Epub ahead of print]
11/10/2011
Un estudi mostra que la temperatura controla el missatge genètic
L'splicing alternatiu, el mecanisme que permet a un gen codificar diferents proteïnes en funció de les necessitats de la cèl·lula, encara amaga molts secrets. Ha transformat la teoria inicial d'"un gen, una proteïna" però quina és la seva estratègia de control segueix sent, en gran part, un misteri. Ara, un equip d'investigadors ha descobert una nova estratègia de control: la temperatura. L'equip, dirigit per Josep Vilardell, investigador ICREA a l'Institut de Biologia Molecular de Barcelona del CSIC i en el que participen Eduardo Eyras investigador ICREA i Mireya Plass, ambdós investigadors del Grup de Genòmica Computacional del GRIB (UPF-IMIM) , ha descobert que la temperatura afecta l'estructura de l'RNA i que, d'aquesta manera, controla quines parts de la seqüència genètica li interessa utilitzar. Treball de referència: Meyer M, Plass M, Pérez-Valle J, Eyras E, Vilardell J. Deciphering 3'ss Selection in the Yeast Genome Reveals an RNA Thermosensor that Mediates Alternative Splicing", Molecular Cell, 2011; Volum 43 (6): 1033-1039
6/10/2011
Certara to Distribute Leading Software for Predicting Off-Target Effects of Small Molecules developed by Chemotargets, the first spin-off company of IMIM
Certara, a leading provider of software and services to improve productivity and decision-making from drug discovery through clinical development, announced that it will be the exclusive provider of Chemotargets software for predicting the off-target pharmacology of small molecules. Chemotargets emerged in 2006 as a spin-off company of the Chemogenomics Laboratory of GRIB led by Dr. Jordi Mestres. “In the last few years, it has been shown that our perception of drug selectivity has been historically biased by the limited amount of pharmacological data available; having a computational tool that allows for extending the currently known target affinities with additional predicted off-target affinities is a means to having a more realistic picture of how drugs may actually exert their action,” said Dr. Mestres.
GRIB volley teams awarded in the PRBB finals of the Beach Volleyball Championship
The Sandrover team was awarded as the best of 4*4 championship and the Vollywood team was awarded with the "Fair play prize" and the "most original team name prize". They did not miss the traditional swim in the sea. Congratulations to all the participants!!
15/7/2011
La bioinformàtica permet tenir un coneixement modular de les malalties genètiques
La recerca s'ha publicat a mitjans de juny en la revista Public Librery of Science ONE.
Un equip d'investigadors del GRIB (UPF-IMIM), conjuntament amb investigadors de la Universitat de Munic (Alemanya), a partir de la xarxa DisGeNET desenvolupada per l'equip que coordina Laura Furlong, investigadora del grup d'Informàtica Biomèdica Integrada del GRIB (UPF-IMIM), han realitzat un treball en què, a més d'una exhaustiva descripció dels gens relacionats amb les malalties considerades, ha tingut en compte altres aspectes biològics que concorren en una determinada malaltia o grup de malalties. La recerca s'ha publicat a mitjans de juny en la revista Public Librery of Science ONE. Treball de referència:Bauer-Mehren A, Bundschus M, Rautschka M, Mayer MA, Sanz F, Furlong LI (2011), " Gene-Disease Network Analysis Reveals Functional Modules in Mendelian, Complex and Environmental Diseases", PLoS ONE, 6(6): e20284
El GRIB forma part de la delegació catalana que assisteix a BIO Washington 2011
La trobada mundial més important del sector biotecnològic se celebrarà aquest any, del 27 al 30 de juny, a Washington DC
La trobada mundial més important del sector biotecnològic se celebrarà aquest any, del 27 al 30 de juny, a Washington DC, la capital dels Estats Units, i un dels nuclis en ciències de la vida que més ha crescut en aquest país els darrers anys. Les oportunitats que ofereix la localització d’aquesta propera edició de la BIO International Convention són tant de l’àmbit pròpiament biotec i farma com del polític El GRIB (IMIM-UPF) hi participa en el marc del estand del Biocat, conjuntament amb 17 centres de recerca i institucions catalanes, a través del seu responsable de transferència. La participació global d'entitats catalanes és de 59, entre empreses amb estand propi, institucions i empreses acollides pel Biocat.
Biomedicina computacional y efectos adversos (Diario Médico, 23/6/2011)
Contra los riesgos, cualquier seguridad es poca. En el caso de los fármacos, una de las últimas armas es la biomedicina computacional. Aquí entra el proyecto europeo EU-ADR, dentro del cual se sitúa un trabajo de sustanciación de señales de farmacovigilancia. Hasta que finalice el presente año, los investigadores se afanarán en lograr métodos mediante los cuales puedan descubrir posibles efectos adversos de los medicamentos.
7/6/2011
A major step in molecular simulation - key to designing new drugs
The research has been published online in the prestigious magazine Proceedings of the National Academy of Sciences (PNAS) Researchers of GRIB (IMIM/ UPF) have successfully reproduced and reconstructed the complete process of a small molecule binding with its target protein. This advance enables the drug's affinity and binding level with the protein to be calculated as well as understanding the interactions established by the drug in order to act, thus moving towards safer and more efficient design of new drugs. This groundbreaking project helps show a process that was hitherto invisible and therefore unknown, and opens up a new avenue in the design of new drugs. Reference article:"Complete reconstruction of an enzyme-inhibitor binding process by molecular dynamics simulations" I Buch, T Giorgino, G De Fabritiis.
