Tools
3/6/2011
eTOX in heart toxicity test breakthrough
Scientists of GRIB (IMIM-UPF) in the IMI project eTOX have developed a computer model to test potential medicines for cardiotoxicity. Currently, many promising drug candidates fail because they turn out to cause serious heart problems in patients. The new eTOX system should help researchers pick up on these problems earlier on in the drug development process. Users simply have to enter the molecular formula of the compound into the tool, and the system generates a simulated ECG (electrocardiograph). Clinicians routinely use ECGs to diagnose heart problems in their patients; in the same way, users can study the simulated ECG generated by the eTOX system to determine whether or not a compound is toxic to the heart. ‘It provides better results than the currently used computational systems,’ commented eTOX project coordinator Ferran Sanz of Fundació IMIM in Spain. Publication ref.: Obiol-Pardo C, Gomis-Tena J, Sanz F, Saiz J, Pastor M. A Multiscale Simulation System for the Prediction of Drug-Induced Cardiotoxicity. Journal of Chemical Information and Modeling, 2011.
3/6/2011
Semantic 'lego': an information framework to drive drug discovery (Press Release)
A new consortium of European organisations unite to support next generation drug discovery by providing a single view across data sources, bringing the semantic web to drug discovery. The Open PHACTS consortium, funded by the Innovative Medicines Initiative, will reduce the barriers to drug discovery by applying semantic technologies to available data resources, creating an Open Pharmacological Space.
20/5/2011
GRIB organizes a Course on Bioinformatics for Integrative Genomics
We are pleased to announce that registration for the Course on Bioinformatics for Integrative Genomics for June 21th- 22th at UPF facilities is now open.The course is organized by the Biomedical Genomics lab of GRIB (IMIM-UPF). The objective of the course is to provide theoretical and practical expertise in the field of bioinformatics for integrative genomics. Attendees will learn how to handle and analyze genomic data to answer specific questions using tools developed in the Biomedical Genomics lab: IntOGen, Gitools and Condel. Registration is free, but limited places available. We strongly recommend you to register asap. To register: send a CV and a motivation letter to Melquíades Calzado(mcalzado@imim.es).
27/4/2011
Jornada sobre patents en l'àmbit de la Biomedicina
Auditori del Parc de Recerca Biomèdica de Barcelona de 10:00 a 14:00h
En el marc de la Plataforma Tecnológica Española de Medicamentos Innovadores, copresidida per Ferran Sanz, director del Programa de Recerca en Informàtica Biomèdica de l'IMIM (Institut de Recerca Hospital del Mar), s'organitza el proper 24 de maig a l'Auditori del Parc de Recerca Biomèdica de Barcelona (PRBB), una Jornada sobre patents en l'àmbit de la biomedicina. Aquesta jornada està dirigida pel professor Pascual Segura, agent de la propietat industrial de la Universitat de Barcelona i director del seu centre de patents. L'objectiu de la Jornada és explicar la importància dels drets de propietat industrial, què es pot patentar i sota quines condicions, entre molts altres temes. La inscripció que és gratuïta podeu realitzar-la clicant aquí.
5/4/2011
GRIB coordinates the new EU funded project INBIOMEDvision
INBIOMEDvision is a Coordination and Support Action funded for two years by the 7thFramework Programme of the European Commission and devoted to the organisation and execution of different activities to support the Biomedical Informatics research field. The project consortium is constituted by seven European academic institutions and coordinated by Ferran Sanz, Director of GRIB (IMIM-UPF).
5/5/2011
Thesis of Alice Ledda: “Distribution and evolution of short sequence tandem repeats in eukaryotic genomes”
Tomorrow 6th of May, Alice Ledda, member of Computational Genomics Group of GRIB (IMIM/UPF) will defence her thesis at 11: 00 at room Josep Marull, Dr. Aiguader 80.
15/4/2011
GRIB participates in the project OPEN PHACTS funded by IMI
The OpenPHACTS consortium comprises 14 European academic institutions and SME partners and 8 pharmaceutical companies. Ferran Sanz leads the participation of the Research Programme on Biomedical Informatics GRIB (IMIM-UPF) in this project. The GRIB will coordinate the project work package that will be in charge of the development of applications for the exploitation of the new knowledge resource in order to afford drug discovery questions. The OpenPHACTS aim is to develop an enabling knowledge infrastructure for the drug discovery projects on the basis of the semantic web technology operating on information that is freely available in the public domain.
18/3/2011
The tools IntOGen and Gitools added to the software portfolio of GRIB
These tools have been developed by the Biomedical Genomics Group of GRIB headed by Nuria López-Bigas. Integrative OncoGenomics (IntOGen) is a discovery tool for cancer researchers, is a resource that integrates multidimensional OncoGenomics Data for the identification of genes and groups of genes (biological modules) involved in cancer development. Gitools is an open-source tool to perform analyses and visualize data and results as interactive heat-maps. Gitools contains data import systems from several sources (i.e. IntOGen, Biomart, KEGG), which facilitate the integration of novel data with previous knowledge.
21/2/2011
Una simulació permet predir arítmies causades per nous candidats a fàrmacs
La toxicitat que provoquen alguns fàrmacs sobre els òrgans vitals com ara el cor, el fetge o el cervell, representa un dels grans obstacles per a l'èxit en el desenvolupament de nous medicaments. Els nous mètodes de predicció per simulació computacional obren nous horitzons en aquest camp. Manuel Pastor, coordinador del grup de recerca de Disseny de Fàrmacs Assistit per Ordinador del GRIB (IMIM-UPF) ha dirigit un treball realitzat amb Ferran Sanz, Director del GRIB, amb membres del grup de Bioelectrònica de la Universitat Politècnica de València, publicat al Journal of Chemical Information and Modeling que, a més, serà portada de l'edició impresa. Treball de referència:Cristian Obiol-Pardo, Julio Gomis-Tena, Ferran Sanz, Javier Saiz i Manuel Pastor (2011), " A Multiescale Simulation System for the Prediction of Drug-Induced Cardiotoxicity", Journal of Chemical Information and Modeling, 20 de gener.
18/2/2011
IV Conferencia Anual de las Plataformas Tecnológicas de Investigación Biomédica: Medicamentos Innovadores, Nanomedicina y Tecnología Sanitaria: Fomentando la cooperación Farma-Biotech.
La cita anual de las tres Plataformas Tecnológicas de Investigación Biomédica abordará la cooperación farma-biotech, como una necesidad puesta de manifiesto en el modelo de investigación de nuevos medicamentos y tecnologías sanitarias. FIMIM, coordinador junto con Farmaindustria de la Plataforma Española de Medicamentos Innovadores, patrocina esta conferencia que tendrá lugar en el Palacio Municipal de Congresos de Madrid, Avda. de la Capital de España s/n Campo de las Naciones. Fecha límite de inscripción: 23 de Febrero.
