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Structural Bioinformatics

Research Outline

Protein-protein interactions play a relevant role among the different functions of a cell. Identifying the protein-protein interaction network of a given organism (interactome) is useful to shed light on the key molecular mechanisms within a biological system. A paradox in protein-protein binding is to explain how the unbound proteins of a binary complex recognize each other among a large population within a cell and how they find their best docking interface in a short time-scale. We interrogate protein structure to unveil its function, generate the network of interactions and to relate genes/proteins with diseases by means of exploiting the topology of the network.

Current Projects/Research Lines

  • Study of the relationship between sequence, structure and function of proteins. Characterization of the structural motifs involved in the function and interactions between proteins. Development of statistical potentials and analysis of physico-chemical potentials helping to describe the fold and function of proteins and its interactions with other macro-molecules.
  • Prediction of protein-protein and protein-DNA interations. Structural analysis of docking aproaches and development of new techniques towards the prediction of binding sites and the mechanisms of interface selection of protein-protein and protein-DNA interactions.
  • Analysis of protein interaction networks and its use on bio-medicine, helping to detect potential targets and prioritization of candidate disease-genes. Development of methods to study and integrate information for different types of networks and application on the study of metastasis. Prediction of signalling networks, such as the phosphorylation network and other post-tran-scriptional modifications, and integration with genomic data, such as microarrays.

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