Thursday, 19th January, 2012, 11:00-12:00,

Template Based Protein-Protein Interaction Prediction and Towards Structural Interactomes

Protein–protein interaction networks provide valuable information in understanding of cellular functions and biological processes. Recent advances in high-throughput techniques have resulted in large amount of data on protein-protein interactions and lead to construction of large protein-protein interaction networks. However, these networks lack structural (3D) details of most interactions, and these structural details are the key components usually for understanding the function of proteins. Therefore, integrating structural information into protein networks on the proteome scale is important because it allows prediction of protein function, helps drug discovery and takes steps toward genome-wide structural systems   biology. In this talk, a fast method for structural modeling of protein-protein interactions that combines template-interface-based docking with flexible refinement will be presented. Its application towards building structural protein-interaction networks will be discussed with the examples on p53 interactions and E2-E3  interactions. In addition, how the structural networks can help drug discovery along the line of emerging polypharmacology paradigm will be discussed.

Speaker: Prof. ATTILA GURSOY, College of Engineering, Koc University, Istanbul, Turkey

Room Seminar Room “Xipre” 173.06 (PRBB – 1st floor)