Seminars, events & talks

Thursday, 4th July, 2013, 11:00-12:00

Gold, protein and a ribosome: Simulating macromolecular encounters.

How do proteins recognise their diverse binding partners? How do they do this in the macromolecularly crowded and confined cellular environment? How do non-specific interactions affect protein motion and binding? We are developing molecular models and Brownian and molecular dynamics simulation procedures to address such questions [1-3]. I will discuss recent applications, including docking of an N-terminal processing enzyme to the ribosome [4], the binding of proteins to gold nanoparticles [5], and the simulation of protein diffusion and oligomerization in highly concentrated protein solutions [6,7].

[1] Gabdoulline, RR; Wade, RC. J. Am. Chem. Soc. (2009) 131, 9230-9238.

[2] Mereghetti, P. and Wade, R.C. J Phys Chem B. (2012) 116, 8523-33.

[3] Kokh, D.B., Corni, S., Winn, P.J., Hoefling, M., Gottschalk, K.,E., Wade, R.C. J.Chem. Theor. Comp. (2010) 6, 1753-68.

[4] Sankdikci, A., Gloge, F., Martinez, M., Mayer, M.P., Wade, R.C., Bukau, B., Kramer, G., Nat. Struct. Mol. Biol. (2013), in press.

[5] Brancolini, G., Kokh, D.B., Calzolai, L., Wade, R.C., Corni, S. ACS Nano. (2012), 6, 9863-78

[6] Mereghetti, P. and Wade, R.C. AIP Conf. Proc., (2013) 1518, 511.

[7] Balbo, J., Mereghetti, P., Herten, D-P, Wade, R.C.  Biophys. J., (2013) 104, 1576-84.

Speaker: Rebecca C. Wade, Heidelberg Institute for Theoretical Studies (HITS), and Zentrum für Molekulare Biologie (ZMBH), Heidelberg University, Germany

Room Xipre (seminar 173.06-183.01), PRBB.

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