Seminars, events & talks

Wednesday, 27th April, 2016, 12:00

Characterization of DNA sequence variants that affect pre-mRNA processing in multiple cancer types

In our lab we study alterations in splicing in multiple cancer types. These splicing alterations occur through somatic mutations in cis in introns and exons or through other mechanisms in trans. We recently published the largest analysis to date of the splicing alterations in cancer (Sebestyen et al. 2016) that includes an exhaustive analysis of the mutations, copy number variations and expression changes in RNA binding proteins and how these impact alternative splicing in multiple cancer. Our previous work lead us to some open ended question about mutations that affect splicing in cis. Therefore, currently we are developing a method for identifying and characterizing significantly mutated regions (SMRs) inside genes from whole genome sequencing (WGS) data and their impact on RNA processing in multiple tumors. I will be presenting some preliminary results about this project.

Speaker: Babita Singh - Computational Genomics group of GRIB (IMIM-UPF)

Room Aula room 473.10 (4th floor)

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