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Seminars, events & talks

Wednesday, 4th May, 2016, 14:00

GPCR drug discovery

Tumour genomes shed light into mutational processes and cancer vulnerabilities

Speaker: Núria López-Bigas - Head of the Computational Genomics group of GRIB (IMIM-UPF)

Room Sala Marie Curie - Ground floor - PRBB

Thursday, 31th March, 2016, 12:00

GPCR drug discovery

"Using protein regions to analyze cancer mutation profiles"

Speaker: Eduard Porta-Pardo - Sanford Burnham Prebys Medical Discovery Institute Bioinformatics, Genomics, Cancer, La Jolla, CA, USA

Room Aula room 473.10 (4th floor)

Thursday, 29th October, 2015, 12:00

GPCR drug discovery

Nucleotide excision repair is impaired by binding of transcription factors to DNA

Somatic mutations are one of the major genetic alterations that contribute to the transformation of normal cell into cancer cell. The rate of somatic mutations appear in great variability across the genome due to chromatin organization, DNA accessibility and replication timing. However, other variables that may influence the mutation rate locally, such as DNA-binding proteins, are unknown. Here we demonstrate that the rate of somatic mutations in melanoma tumors is highly increased at active transcription factor binding sites and nucleosome embedded DNA compared to their flanking regions due to impaired nucleotide excision repair activity.


Room Aula room (4th floor)

Tuesday, 7th July, 2015, Wednesday, July 8 at 12:00h

GPCR drug discovery

Long non-coding RNAs as a source of new peptides.

High throughput sequencing of the eukaryotic transcriptome has resulted in the identification of many transcripts that lack long conserved open reading frames and which have been classified as long non-coding RNAs (lncRNAs). The majority of them are expressed at low levels and do not have a known function. Despite having been annotated as non-coding RNAs, the sequencing of ribosome-protected RNA fragments (ribosome profiling) has revealed that many of them are scanned by ribosomes and are likely to translate short peptides. We have examined single nucleotide polymorphism (SNP) data and have found evidence of purifying selection on the corresponding coding regions. We propose that lncRNAs provide the necessary raw material for the evolution of new functional proteins during evolution.

Group Leader Seminars are always on Wednesdays at 12:00h at the Auditorium, Sala Marie Curie or, exceptionally, at the Aula 473.

Speaker: Mar Albà

Room PRBB Auditorium

Friday, 15th May, 2015, 12:00

GPCR drug discovery

Targeted DNA- and RNA sequencing of cancer predisposition genes and B-cell repertoire

Speaker: Marton Munz, PhD. Wellcome Trust Centre for Human Genetics, University of Oxford

Room Sala Xipre

Thursday, 26th March, 2015, 11:00h

GPCR drug discovery

Chromatin regulatory factors in tumorigenesis: Molecular mechanisms and potential targeting strategies

Speaker: Joan Frigola- Biomedical Genomics group - GRIB (IMIM-UPF)

Room 473.10

Thursday, 5th March, 2015, 11:00

GPCR drug discovery

Identification of recently evolved genes in human and chimpanzee using deep

For a very long time, major mechanisms driving the evolution of new genes were thought to be restricted to gene duplication or rearrangements in existing protein-coding material. Nevertheless, recent comparative genomic analyses have shown that some genes are originated de novo from previously non-functional genomic sequences. These recently evolved genes may be related with the emergence of species or lineage specific adaptations.

Speaker: Jorge Ruiz Orera. Evolutionary Genomics Group, GRIB (IMIM-UPF)

Room 473.10_AULA

Thursday, 23th October, 2014, 11:00

GPCR drug discovery

Analysis and visualization of multidimensional cancer genomics data

Cancer is a complex disease caused by somatic alterations of the genome and epigenome in tumor cells. Increased investments and cheaper access to various technologies have built momentum for the generation of cancer genomics data. The availability of such large datasets offers many new possibilities to gain insight into cancer molecular properties. Within this scope we'll present two methods that exploit the broad availability of cancer genomic data: Oncodrive-ROLE, an approach to classify mutational cancer driver genes into activating and loss of function mode of actions and MutEx, a statistical measure to assess the trend of the somatic alterations in a set of genes to be mutually exclusive across tumor samples. Nevertheless, the unprecedented dimension of the available data raises new complications for its accessibility and exploration which we try to solve with new visualization solutions: i) Gitools interactive heatmaps with prepared large scale cancer genomics datasets ready to be explored, ii) jHeatmap, an interactive heatmap browser for the web capable of displaying multidimensional cancer genomics data and designed for its inclusion into web portals.

Speaker: Michael Schroeder - Biomedical Genomics group of GRIB

Room Sala Ramón y Cajal

Wednesday, 8th October, 2014, 8-14/10/2014

GPCR drug discovery

V Beyond The Genome: Cancer Genomics, Harvard Medical School, Boston ( USA). Lopez Bigas, Nuria. Organizing committee.

Thursday, 19th June, 2014, 11:00

GPCR drug discovery

The cancer genome interpreter identifying relevant cancer mutations in a patient

PRBB Computational Genomics Seminars.

Speaker: Abel González Pérez - Biomedical Genomics - GRIB

Room Sala 473.10

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