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Seminars, events & talks

Thursday, 26th March, 2015, 11:00h

GPCR drug discovery

Chromatin regulatory factors in tumorigenesis: Molecular mechanisms and potential targeting strategies

Speaker: Joan Frigola- Biomedical Genomics group - GRIB (IMIM-UPF)

Room 473.10

Thursday, 5th March, 2015, 11:00

GPCR drug discovery

Identification of recently evolved genes in human and chimpanzee using deep

For a very long time, major mechanisms driving the evolution of new genes were thought to be restricted to gene duplication or rearrangements in existing protein-coding material. Nevertheless, recent comparative genomic analyses have shown that some genes are originated de novo from previously non-functional genomic sequences. These recently evolved genes may be related with the emergence of species or lineage specific adaptations.

Speaker: Jorge Ruiz Orera. Evolutionary Genomics Group, GRIB (IMIM-UPF)

Room 473.10_AULA

Tuesday, 20th January, 2015, 11:00-12:00

Structural Bioinformatics

A library of eukaryotic transcription factors, and its application for understanding disease

Speaker: Matthew T. Weirauch; Assistant Professor, Dept. of Pediatrics, University of Cincinnati.

Room Xipre (seminar 173.06-183.01), PRBB.

Friday, 12th December, 2014

Integrative Biomedical Informatics

II Bioinformatics and Computational Biology Symposium


This event, jointly organized by the Societat Catalana de Biologia (SCB) and Bioinformatics Barcelona (BIB) will take place at the Institut d'Estudis Catalans on the 12th of December 2014 and  will have four great Keynote speakers and a selection of 8 abstracts for the oral presentations. Additional information can be found in this Web site: http://sgt.cnag.cat/JdB2014/ Registration closes: 30th of November 2014

Speaker: John Overington (EBI-EMBL), David Posada (U. Vigo), Alfonso Valencia (CNIO), Ramon Maspons (AQuAS)

Room Institut d'Estudis Catalans

Wednesday, 10th December, 2014, 18:45

Integrative Biomedical Informatics

Real world data from Catalonia

This talk is included in the agenda of the European Medical Information Framework (EMIF) Colloquium.

The event will be held on December 10, between 18:00 - 20:00 at the Barcelona Biomedical Research Park (PRBB) auditorium. It will be followed by a networking drink on the PRBB terrace.  There will be simultaneous interpretation available. Please register your attendance by 30th November at http://emif.concentris.de For more information on the EMIF Project see website: http://www.emif.eu/

Speaker: Ferran Sanz, Director of GRIB

Room PRBB Auditorium

Wednesday, 3rd December, 2014, 12.00-13.00

Computational Biophysics

Rational design of antibodies targeting intrinsically disordered proteins

In biological systems nearly all processes are governed by interactions between protein molecules, which have evolved to perform an innumerable variety of functions. The ability of some proteins, such as antibodies, to interact with high affinity and specificity is being increasingly exploited for therapeutic and diagnostic applications. Yet, using current methods it is laborious and often difficult to generate antibodies against specific epitopes within a protein, in particular within disordered regions. Likewise, the successful development of antibody-based drugs is often hindered by their relatively poor solubility, which leads to aggregation at the high concentrations necessary for effective storage and delivery. 
I will present two computational approaches to rationally modify interactions between protein molecules, including antibodies. The aim of the first is to hamper aberrant interactions by predicting mutations that improve the solubility, while retaining native state and activity. Its application to a single-domain antibody demonstrates that solubility changes upon mutation are estimated with great accuracy, thus offering a cost-effective strategy for the production of soluble proteins. The second consists in the rational design of protein-protein interactions by engineering a scaffold to bind to virtually any target disordered epitope in a protein. We validate this method by designing five single domain antibodies to bind different epitopes within three disease-related intrinsically disordered proteins (α-synculein, Aβ and IAPP). The results show that all antibodies bind to their target with good affinity and specificity. As an example of an application we carried out further experiments on one of these antibodies to show that it inhibits the aggregation of α-synuclein at low substoichiometric concentrations, and that binding indeed occurs at the selected epitope.

Speaker: Pietro Sormanni, PhD Student, Department of Chemistry, University of Cambridge, Cambridge

Room Aula room (470.03 – 4th floor)

Thursday, 20th November, 2014, 11:00-12:00

Computational RNA Biology

Recent Developments in RNA structure prediction and RNA design

Speaker: Ivan Dotu; Biology Department, Boston College.

Room Aula room (470.03 – 4th floor)

Tuesday, 11th November, 2014

Integrative Biomedical Informatics

b·debate "Big Data in Biomedicine. Challenges and opportunities". Sanz, Ferran. Comitè organitzador


Barcelona, 11-12/11/2014. organitzada juntament amb Bioinformatics Barcelona (BIB),  European Bioinformatics Institute (EMBL-EBI), Biocat i Fundació La Caixa.

Monday, 10th November, 2014, 12:30

Integrative Biomedical Informatics

Bioinformatics in the Era of Big Data

Bio{medical}informatics is a field that has emerged through the analysis of data primarily generated by other researchers. As such it is a leading indicator for what biomedical research will involve in the era of big data, taken here to imply large diverse datasets at different biological   scales - from molecules to populations. Does the model by which we have accessed such data thus far scale to the future? I will argue that the answer is no and new approaches are needed which would change how we do our science.

Speaker: Philip E. Bourne, Associate Director for Data Science (ADDS) at the National Institutes of Health (USA)

Room Ramon y Cajal

Thursday, 23th October, 2014, 11:00

GPCR drug discovery

Analysis and visualization of multidimensional cancer genomics data

Cancer is a complex disease caused by somatic alterations of the genome and epigenome in tumor cells. Increased investments and cheaper access to various technologies have built momentum for the generation of cancer genomics data. The availability of such large datasets offers many new possibilities to gain insight into cancer molecular properties. Within this scope we'll present two methods that exploit the broad availability of cancer genomic data: Oncodrive-ROLE, an approach to classify mutational cancer driver genes into activating and loss of function mode of actions and MutEx, a statistical measure to assess the trend of the somatic alterations in a set of genes to be mutually exclusive across tumor samples. Nevertheless, the unprecedented dimension of the available data raises new complications for its accessibility and exploration which we try to solve with new visualization solutions: i) Gitools interactive heatmaps with prepared large scale cancer genomics datasets ready to be explored, ii) jHeatmap, an interactive heatmap browser for the web capable of displaying multidimensional cancer genomics data and designed for its inclusion into web portals.

Speaker: Michael Schroeder - Biomedical Genomics group of GRIB

Room Sala Ramón y Cajal



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