GRIB. Research Unit on Biomedical Informatics





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Imatge de microscopia que mostra les cèl·lules piramidals de l'hipocamp del ratolí Thy1-EGFP

A mechanism whereby cannabis would affect the plasticity of neural circuits is identified

A study led by Andrés Ozaita, a researcher at the Neuropharmacology Laboratory at UPF, shows how the main psychoactive component of cannabis affects the machinery required to maintain the protein balance in the hippocampus. They have discovered a mechanism whereby the cannabis would affect synaptic plasticity, i.e., the neurons' ability to respond to stimuli, modifying their connections, which are essential for learning and memory. The study, conducted in rodents, has been published in the journal Biochemical Pharmacology. The study also involved Joaquim Aguirre-Plans, Baldo Oliva and Emre Guney, researchers of the Structural Bioinformatics and Integrative Bioinformatics groups of GRIB.

Reference article: Salgado-Mendialdúa V, Aguirre-Plans J, Guney E, Reig-Viader R, Maldonado R, Bayés A, Oliva B, Ozaita A. Delta9-tetrahydrocannabinol modulates the proteasome system in the Brain. Biochemical Pharmacology (2018), https://doi.org/10.1016/j.bcp.2018.08.026.

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Participants in the think tank meeting in Ranco, Italy

GRIB participates in the think tank meeting co-organized by the Center for Animal Alternatives to Testing-Europe and the project EU-ToxRisk.

The meeting took place in Ranco, Italy from 16th to 18th of July 2018 and was focused on "Internationalisation of read across as validated non-animal method (NAM) for regulatory toxicology". More than 20 read-across international experts from regulatory agencies, industry, and academia met to discuss about the necessary steps which would be necessary to boost the standardization of the read-across method and to expand its use and acceptance among international regulatory organizations. Manuel Pastor, head of the  PharmacoInformatics group of GRIB and leader of the workpackage applying read across methods within the EU-ToxRisk project, participated on this meeting.

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eTRANSAFE

The project eTRANSAFE: Enhancing Translational Safety Assessment through Integrative Knowledge Management, aims to develop an advanced data integration infrastructure together with innovative computational methods to improve the security in drug development process. The project is funded by the Innovative Medicines Initiative (IMI 2) together with the pharmaceutical industry for the period 2017-2022 and is coordinated by the GRIB. 

http://www.etransafe.eu/

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