En la complexitat dels éssers vius intervenen propietats físico-químiques del medi cel·lular
Un treball dirigit per Eduardo Eyras, investigador ICREA i responsable del Grup de Regulació Genòmica del GRIB (IMIM-UPF) mostra com les formes o estructures secundàries d'ARN regulen l'splicing o empalmament alternatiu en cèl·lules de llevat (Saccharomyces cerevisiae) emprades com a model experimental.
S'ha comprovat que aquestes conformacions secundàries de l'ARN estan modificades per propietats físiques i químiques intrínseques de la cèl·lula, com ara la temperatura i el pH.
Treball de referència: Plass M, Codony-Servat C, Ferreira PG, Vilardell J, Eyras E. RNA secondary structure mediates alternative 3'ss selection in Saccharomyces cerevisiae. RNA, 2012.
Beyond Omics Revolutions: Integrative Knowledge Management for Empowered Healthcare and Research
These debate sessions led by Ferran Sanz (GRIB Director) and coorganized by the GRIB (IMIM-UPF) and the Internatinal Center for Scientific Debate B·Debate will bring together scientists and specialists from the many disciplines related to biomedical informatics in order to discuss the challenges, needs and opportunities of developing translational bioinformatics as a key tool for achieving more effective and personalized medicine.
Date: July, 3rd, 4th and 5th, 2012
Place: CaixaFòrum Barcelona
RNPnet
RNAs associate with proteins to form highly complex and dynamic ribonucleoprotein (RNP) complexes. The goal of this Marie Curie ITN is first to bring together existing labs from different discipline, to join forces and tackle key questions in the field, and second, to produce highly-trained young researchers that will be sensitized to RNA and possess a multidisciplinary approach to research.
- Flachner B, Lörincz Z, Carotti A, Nicolotti O, Kuchipudi P, Remez N, Sanz F, Tóvári J, Szabó MJ, Bertók B, Cseh S, Mestres J, Dormán G. A chemocentric approach to the identification of cancer targets. PLoS ONE, 2012; 7: 4. PMID: 22558171 . DOI: e35582.
- Plass M, Codony-Servat C, Ferreira PG, Vilardell J, Eyras E. RNA secondary structure mediates alternative 3'ss selection in Saccharomyces cerevisiae. RNA, 2012. . PMID: 22539526 .
- Giorgino T, Buch I, De Fabritiis G. Visualizing the Induced Binding of SH2-Phosphopeptide. J Chem Theory Comput, 2012; 8 (4): 1171-1175 DOI: 10.1021/ct300003f.
- Erb I, González-Vallinas JR, Bussotti G, Blanco E, Eyras E, Notredame C. Use of ChIP-Seq data for the design of a multiple promoter-alignment method. Nucleic Acids Res, 2012; 40 (7): e52. PMID: 22230796 .
Research labs
