GRIB. Research Unit on Biomedical Informatics





News & activities

Come to the GRIB EXPO the 10th November 2014

Come to the GRIB EXPO, a scientific exhibition on biomedical informatics. It will take place at Barcelona Biomedical Research Park (PRBB) the 10th of November with the participation of Philip E. Bourne as guest lecturer. You will have the chance to interact with scientist working on computational tools to shape the future of healthcare and drug discovery. 

Participation is free and open to all academic, industrial or health organizations within the PRBB and beyond. Registration is compulsory. Please click here for registration or send a mail to coliver@imim.es

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The new voyage of the 'Argonautes'

Researchers of the Computational Genomics group of GRIB (IMIM-UPF) led by Eduardo Eyras, CRG, University of Buenos Aires and the Max Planck Institute in Gottingen have recently published a study in PNAS, reporting that Argonaute proteins play an important role in the regulation of genes in the cell nucleus. The published work describes how Argonaute proteins, besides their role in post-transcriptional regulation, can also affect gene expression during transcription, the cell process that makes mRNA from DNA.

Reference paper: Allo M, Agirre E, Bessonovc S, Bertucci P, Gómez-Acuña L, Buggiano V, Bellora N, Singh B, Petrillo E, Blaustein M, Miñana B, Dujardin G, Pozzi B, Pelisch F, Bechara E, Agafonov D, Srebrow A, Lührmann R, Valcárcel J, Eyras E , Kornblihtt AR. Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells. PNAS, 2014

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Last project

eTOX

Integrating bioinformatics and chemoinformatics approaches for the development of expert systems allowing the in silico prediction of toxicities. European project funded by IMI, extended until 2016 and coordinated by the GRIB. The eTOX project aims to develop a drug safety database from the pharmaceutical industry legacy toxicology reports and public toxicology data, innovative in silico strategies and novel software tools to better predict the toxicological profiles of small molecules in early stages of the drug development pipeline.

http://www.e-tox.net/index.html

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Last publications

  • Martí-Solano M, Sanz F, Pastor M, Selent J. A dynamic view of molecular switch behavior at serotonin receptors: implications for functional selectivity. PLoS One, 2014; 9(10):e109312 . PMID: 25313636 . DOI: 10.1371/journal.pone.0109312. eCollection 2014..
  • Alló M, Agirre E, Bessonov S, Bertucci P, Gómez Acuña L, Buggiano V, Bellora N, Singh B, Petrillo E, Blaustein M, Miñana B, Dujardin G, Pozzi B, Pelisch F, Bechara E, Agafonov DE, Srebrow A, Lührmann R, Valcárcel J, Eyras E, Kornblihtt AR. Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells. Proc Natl Acad Sci U S A, 2014; . PMID: 25313066 .
  • Raj B, Irimia M, Braunschweig U, Sterne-Weiler T, O'Hanlon D, Lin ZY, Chen GI, Easton LE, Ule J, Gingras AC, Eyras E, Blencowe BJ. A Global Regulatory Mechanism for Activating an Exon Network Required for Neurogenesis. Mol Cell, 2014. PMID: 25219497 . DOI: 10.1016/j.molcel.2014.08.011.
  • Tur I, Roverato A, Castelo R. Mapping eQTL Networks with Mixed Graphical Markov Models. Genetics, 2014. PMID: 25271303 .

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