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40 Million EUR european project for new drug safety assessment and integrative data analysis research

The five-year project eTRANSAFE: Enhancing Translational Safety Assessment through Integrative Knowledge Management, aims to develop an advanced data integration infrastructure together with innovative computational methods to improve the security in drug development process and is funded by the Innovative Medicines Initiative (IMI 2) together with the pharmaceutical industry.

The eTRANSAFE consortium is a private and public partnership of 8 academic institutions, 6 SMEs and 12 pharmaceutical companies, and is coordinated by the Fundació Institut Mar d'Investigacions Mèdiques (IMIM) and led by the pharmaceutical company Novartis. Universitat Pompeu Fabra and Synapse Research Management Partners are partners of the Consortium. 

Based on the experience gained in the previous eTOX project, the eTRANSAFE project will carry out key efforts in the field of data standardisation and quality control, promoting the development and implementation of relevant data sharing policies and procedures that will have a great global impact in the community. eTRANSAFE will catalyse the transformation of drug safety modelling from monolithic applications and isolated data repositories to an open innovation ecosystem based on open standards, modular components and data integration services.

Professor Ferran Sanz, coordinator of the project said: "eTRANSAFE will improve translational safety assessment and contribute to the key scientific policies, such as the reduce, replace, refine (3Rs) one and the FAIR principles for data sharing."

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El GRIB participa en el Whitepaper sobre análisis de la estrategia Big Data en España

La publicación describe el panorama español del Big Data analizando el estado actual de la investigación, las infraestructuras y las tecnologías existentes en España para identificar los puntos fuertes y los espacios de mejora. El documento recoge el trabajo de recopilación realizado hasta la fecha y el análisis posterior, de cara a identificar proyectos prioritarios y potenciar y difundir el valor existente.  Miguel Ángel Mayer, investigador postdoctoral del Grupo de Informatica Biomédica Integrada del GRIB (IMIM-UPF) es uno de los autores de este whitepaper

La publicación se ha realizado en el marco de la iniciativa nacional multisectorial "Big Data", que surge para dar respuesta a una creciente demanda y expectativas en este dominio. Ha sido promovida por Planetic, la Plataforma Tecnológica Española de las Tecnologias de la Información y la Comunicación.

Dentro del marco Europeo que promueve la creación de un mercado único de datos, se trata en definitiva, de posicionar a España al mismo nivel de la iniciativa europea, descubriendo y dando soluciones a las oportunidades de negocio existentes en torno al Big Data.

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Last project

eTRANSAFE

The project eTRANSAFE: Enhancing Translational Safety Assessment through Integrative Knowledge Management, aims to develop an advanced data integration infrastructure together with innovative computational methods to improve the security in drug development process and is funded by the Innovative Medicines Initiative (IMI 2) together with the pharmaceutical industry for the period 2017-2022. 

http://www.etransafe.eu/

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Last publications

  • Azuaje J, López P, Iglesias A, de la Fuente RA, Pérez-Rubio JM, García D, Stępniewski TM, García-Mera X, Brea JM, Selent J, Pérez D, Castro M, Loza MI, Sotelo E. Development of Fluorescent Probes that Target Serotonin 5-HT2B Receptors. Sci Rep, 2017; 7 (1): 10765. PMID: 28883627 . DOI: 10.1038/s41598-017-11370-2.
  • Kapoor A, Martínez G, Provasi D, de Fabritiis G, Filizola M. Dynamic and Kinetic Elements of µ-Opioid Receptor Functional Selectivity. Sci Rep, 2017; 7(1): 11255. PMID: 28900175 . DOI: 10.1038/s41598-017-11483-8.
  • Albà MM. Zinc-finger domains in metazoans: evolution gone wild. Genome Biol, 2017; 18 (1): 168. PMID: 28877710 . DOI: 10.1186/s13059-017-1307-y.
  • Iglesias A, Cimadevila M, la Fuente RA, Martí-Solano M, Cadavid MI, Cadavid MI, Selent J, Loza MI, Brea J. Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization. Eur J Pharmacol, 2017. PMID: 28899696 . DOI: 10.1016/j.ejphar.2017.09.011.

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