GRIB. Research Unit on Biomedical Informatics





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ESCAPE-NET

EU-wide network explores sudden cardiac arrest causes to help prevention and treatment

Sudden cardiac arrest (SCA) continues to be a major public health challenge, accounting for about 20 % of all natural deaths in industrialised countries. Although there has been a substantial decline in overall coronary heart disease mortality rates in the past 30 years, SCA rates have fallen to a lesser extent. Some 50 % of all cardiovascular deaths are caused by SCA, a condition in which the heart suddenly and unexpectedly stops beating. With survival rates ranging between 5 % and 20 % there's a need to improve SCA prevention and treatment.

To address this issue, a European public-private consortium is now working on the creation of a joint, harmonised database by analysing SCA victims and DNA samples, along with detailed clinical and medication use information. Funded by H2020 Programme of the European Union, the team of scientists contributing to the ESCAPE-NET project, including the System Pharmacology group of GRIB (IMIM-UPF) led by Jordi Mestres, summarised the objectives of their research in the 'European Heart Journal'.

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Foto de Chus Donlo

The 6th iPiE Forum Meeting was held in Barcelona during the 24th and 25th of April 2018

The 6th iPiE Forum Meeting was held in Barcelona during the 24th and 25th of April 2018, and counted with the presence of the participants of the iPiE Consortium. The Integrative Biomedical Informatics group and the PharmacoInformatics group of GRIB (IMIM-UPF) take part of this european project. The meeting was focused on progress to the development of guidance on how the established approaches and expert system from iPiE can be used in the intelligent testing of APIs at early stages in drug development, and to prioritise legacy APIs for further testing or assessment.

On the first day, an integration workshop was organised to define next steps towards the preparation of prioritisation guidelines. The workshop started with two parallel sessions, one attended by academia and other by industry representatives, including regulatory experts in both. The two groups were allowed for an internal debate that led to concrete conclusions on necessities from both sides. The meeting also included the updates of Work Packages and the progress done in the past months.

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eTRANSAFE

The project eTRANSAFE: Enhancing Translational Safety Assessment through Integrative Knowledge Management, aims to develop an advanced data integration infrastructure together with innovative computational methods to improve the security in drug development process. The project is funded by the Innovative Medicines Initiative (IMI 2) together with the pharmaceutical industry for the period 2017-2022 and is coordinated by the GRIB. 

http://www.etransafe.eu/

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