GRIB. Research Unit on Biomedical Informatics





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The version 7.0 of DisGeNET is now available and includes the creation of a new resource for COVID-19

The GRIB Integrative Biomedical Informatics group (IMIM-UPF) has launched a new version of DisGeNET (version 7.0, May 8, 2020), which contains more than 1 million associations between 21,000 genes and 30,000 diseases, and 350,000 associations involving more than 190,000 genomic variants. All the data sources have been updated including the information automatically extracted by text mining of the literature. In addition, a new resource focused on COVID-19 has also been created.

DisGeNET is a public knowledge management platform that offers information on genes and genomic variants associated with human diseases, which is obtained by integrating data from more than a dozen public resources and the scientific literature. DisGeNET contains one of the most comprehensive collections of genes and variants associated with human diseases that is currently available and is a resource for sharing and exchanging information recommended by the ELIXIR project, which is called, ELIXIR Recommended Interoperability Resource.

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Chemotargets opens an investment round to enter a new phase of growth

Chemotargets, a global leader in predictive analytics solutions for the pharma and biotech sector, founded in 2006 by Jordi Mestres, head of the Systems Pharmacology group of GRIB, begins a phase of transformation to become a biotechnology company that will develop new medicines in multiple therapeutic areas, with an initial focus on oncology, opening an investment round to undertake the transformation of its business model.

"We are very motivated to begin a new stage of growth and to discover new bioactive molecules in collaboration with public research centres and pharmaceuticals companies. On this basis, we will consider the creation of new spin-off entities that will discover and develop new potential drugs," says Jordi Mestres, Chemotargets CEO and Head of the Systems Pharmacology Group. The company has developed the ProSurfScan technology, which allows the generation of bioactive molecules using state-of-the-art structure-based, artificial intelligence and data-mining methods for novel therapeutic targets and new interaction modalities (protein - protein, allosteric modulators, etc.).

The health and social crisis caused by SARS-CoV-2 pandemic has encouraged the company to pursue its principles: "We founded Chemotargets to resolve complex biomedical challenges and we have an obligation to join efforts to find solutions to this major challenge," says Jordi Mestres.

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CompBioMed is a European Commission H2020 funded Centre of Excellence focussed on the use and development of computational methods for biomedical applications. It has users within academia, industry and clinical environments and is working to train more people in the use of its products and methods. CompBioMed started on 2016 and has been extended on October 2019 for another 4 years until 2023.

http://www.compbiomed.eu/

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