GRIB. Research Unit on Biomedical Informatics





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Jorge Ruiz Orera receives one of the Doctoral School PhD Special Awards from the PhD Programme in Biomedicine of the Pompeu Fabra University

Congratulations to Jorge Ruiz Orera, doctoral student at the Evolutionary Genomics group of GRIB  (IMIM-UPF) for his thesis "Understanding the mechanisms of de novo gene evolution using transcriptomics data", supervised by Dr. Mar Albà. In his research, he investigated the mechanisms for de novo gene origination and evolution using highthroughput sequencing of complete transcripts and ribosome-protected fragments. The thesis identifies thousands of new de novo genes in human, chimpanzee, and mouse and presents evidence that these genes are mostly expressed from recently arisen promoters. It also shows that a large number of poorly conserved genes, including genes previously believed to be non-coding, are translated and finds a link between the capacity of a sequence to be translated and its nucleotide sequence composition. This doctoral research shows that there is abundant raw material for de novo birth of new functional proteins, and hence, its results contribute to a better understanding of the mechanisms of gene evolution. This thesis has been awarded with the International PhD Mention.

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"We found a way to share the unsharable", an interview with the eTOX project coordinators F. Pognan and F. Sanz

The eTOX project partners developed innovative strategies and novel software tools to better predict the safety and side effects of new candidate medicines for patients. In an interview with the Innovative Medicine Iniciative (IMI) Programme Office, project coordinator Francois Pognan of Novartis, and academic coordinator Ferran Sanz, Director of GRIB (IMIM-UPF), explain how the tools developed by the project are already helping pharmaceutical companies make better-informed decisions in their pursuit of developing safer drugs for patients.

"For the academic world", Ferran Sanz says, "the way in which we have learned how to collaborate with the pharmaceutical industry is potentiating our capabilities to create spin offs and to establish research contracts with the pharmaceutical industry, beyond this particular project".

Read the interview at 'We found a way to share the unsharable' - an interview with the eTOX...

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eTRANSAFE

The project eTRANSAFE: Enhancing Translational Safety Assessment through Integrative Knowledge Management, aims to develop an advanced data integration infrastructure together with innovative computational methods to improve the security in drug development process. The project is funded by the Innovative Medicines Initiative (IMI 2) together with the pharmaceutical industry for the period 2017-2022 and is coordinated by the GRIB. 

http://www.etransafe.eu/

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