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Original articles in indexed journals - GPCR Drug Discovery

Azuaje J, López P, Iglesias A, de la Fuente RA, Pérez-Rubio JM, García D, Stępniewski TM, García-Mera X, Brea JM, Selent J, Pérez D, Castro M, Loza MI, Sotelo E. Development of Fluorescent Probes that Target Serotonin 5-HT2B Receptors. Sci Rep, 2017; 7 (1): 10765 . PMID: 28883627 . DOI: 10.1038/s41598-017-11370-2.

2017

Original articles in indexed journals - GPCR Drug Discovery

Iglesias A, Cimadevila M, la Fuente RA, Martí-Solano M, Cadavid MI, Cadavid MI, Selent J, Loza MI, Brea J. Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization. Eur J Pharmacol, 2017 . PMID: 28899696 . DOI: 10.1016/j.ejphar.2017.09.011.

2017

Original articles in indexed journals - GPCR Drug Discovery

Ramírez-Anguita JM, Rodríguez-Espigares I, Guixà-González R, Bruno A, Varela-Rial A, Selent J. Membrane cholesterol effect on the 5-HT2A receptor: Insights into the lipid-induced modulation of an antipsychotic drug target. Biotechnol Appl Bioc, 2017 . PMID: 28877377 . DOI: 10.1002/bab.1608.

2017

Original articles in indexed journals - GPCR Drug Discovery

Oddi S, Totaro A, Scipioni L, Dufrusine B, Stepniewski TM, Selent J, Maccarrone M, Dainese E. Role of palmitoylation of cysteine 415 in functional coupling CB1 receptor to Gαi2 protein. Biotechnol Appl Bioc, 2017 . PMID: 28722168 . DOI: 10.1002/bab.1575.

2017

Original articles in indexed journals - GPCR Drug Discovery

Oddi S, Stepniewski TM, Totaro A, Selent J, Scipioni L, Dufrusine B, Fezza F, Dainese E, Maccarrone M. Palmitoylation of cysteine 415 of CB1 receptor affects ligand-stimulated internalization and selective interaction with membrane cholesterol and caveolin 1. Biochim Biophys Acta, 2017;  1862 (5): 523-532 . PMID: 28215712 . DOI: 10.1016/j.bbalip.2017.02.004.

2017

Original articles in indexed journals - GPCR Drug Discovery

Lally CCM, Bauer B, Selent J, Sommer ME. C-edge loops of arrestin function as a membrane anchor. Nature Commun, 2017; 8: 14258 . PMID: 28220785 . DOI: 10.1038/ncomms14258.

2017

Original articles in indexed journals - Integrative Biomedical Informatics - PharmacoInformatics - GPCR Drug Discovery

Guixà-González R, Albasanz JL, Rodríguez-Epigares I, Pastor M, Sanz F, Martí-Solano M, Manna M, Martínez-Seara H, Hildebrand PW, Martí M, Selent J. Membrane cholesterol access into a G-protein-coupled receptor. Nat Commun, 2017; 8: 14505 . PMID: 28220900 . DOI: 10.1038/ncomms14505.

2017

Other - PharmacoInformatics - Computational Biophysics - GPCR Drug Discovery

Leon Caballero J, Pastor M, De Fabritiis G, Selent J. New molecular insights into the mechanism of lithium action at the dopaminergic D2 receptor. Eur Neuropsychopharmacol, 2016; 26: S239-S239; S2; 1-44

2016

Original articles in indexed journals - GPCR Drug Discovery

Rodriguez-Espigares I, Kaczor AA, Selent J. In silico Exploration of the Conformational Universe of GPCRs. Mol Inf, 2016; 35 (6-7):227-237 . PMID: 27492237 . DOI: 10.1002/minf.201600012.

2016

Original articles in indexed journals - GPCR Drug Discovery

Martí-Solano M, Schmidt D, Kolb P, Selent J. Drugging specific conformational states of GPCRs: challenges and opportunities for computational chemistry. Drug Discov Today, 2016; 21 (4): 625-631 . PMID: 26821135 . DOI: 10.1016/j.drudis.2016.01.009.

2016



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