GRIB. Research Unit on Biomedical Informatics





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Project iPIE: Testing the environmental impact of drugs

The project iPIE: Intelligence Led Assessment of Pharmaceuticals in the Environment starts on February 2015 with a kick off meeting at Barcelona Biomedical Research Park (PRBB) and the participation of the GRIB research groups of Integrative Biomedical Informatics (IBI) and PharmacoInformatics (PhI).

It is often ignored that any drug administered to human patients ends up in the environment, either in the original form or as a mixture of drug metabolites. Testing the environmental impact of novel drug candidates is therefore important in order to early discard potentially dangerous ones.

With a budget of 10.2 million euros and a duration of 4 years, the project iPIE aims to develop a predictive framework that utilise existing information and in silico models to support more intelligent environmental testing of pharmaceuticals in development and to prioritise legacy pharmaceuticals for full environmental risk assessment and/or environmental (bio) monitoring.

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Thesis defence of Jaume Bonet: "Exploiting protein fragments in protein modelling and function prediction"

On 30rd of January, Jaume Bonet, member of the Structural Bioinformatics group of GRIB (IMIM-UPF) will defend his thesis at 11:00 at Josep Marull Room (QMAR building). You are all invited to this event.

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Last project

iPIE

The project iPIE: "Intelligence Led Assessment of Pharmaceuticals in the Environment", aims to develop a predictive framework that utilise existing information and in silico models to support more intelligent environmental testing of pharmaceuticals in development and to prioritise legacy pharmaceuticals for full environmental risk assessment and/or environmental (bio) monitoring. European project funded by IMI for the period 2015-2017.

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Last publications

  • Coelho MB, Attig J, Bellora N, König J, Hallegger M, Kayikci M, Eyras E, Ule J, Smith CW. Nuclear matrix protein Matrin3 regulates alternative splicing and forms overlapping regulatory networks with PTB. EMBO J, 2015. PMID: 25599992 .
  • Sebestyen E, Zawisza M, Eyras E. Detection of recurrent alternative splicing switches in tumor samples reveals novel signatures of cancer. Nucleic Acids Research, 2015. PMID: 25578962 . DOI: 10.1093 / NAR / gku1392..
  • Carbonell P, Trosset JY. Computational protein design methods for synthetic biology. Methods Mol Biol, 2015; 1244:3-21. PMID: 25487090 . DOI: 10.1007/978-1-4939-1878-2_1..
  • García J. Protein-protein interaction network: management of databases and its applications on the computational study of protein-protein interactions. Universitat Pompeu Fabra. January 23th 2015. Thesis Director: Oliva B.

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